Geoffery Murphy Ph.D.
| 5037 BSRB |
| Ann Arbor, MI 48109 |
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My research program employs a molecular-genetics approach to investigate how changes in neuronal excitability affect learning and memory. Using transgenic mouse models, I am currently pursuing two broad areas of investigation: 1) how age-related changes in neuronal excitability impact cognition and 2) how rapid changes in neuronal excitability alter the ability of the central nervous system to encode, maintain and retrieve information.
McKinney, B. C. & Murphy, G. G. (2006) The L-Type Voltage-Gated Calcium Channel Cav1.3 Mediates Acquisition, but not Extinction, of Contextually-Conditioned Fear in Mice. Learning and Memory. 13(5):584-9.
Murphy, G. G.; Rahnama, N.P.; Silva, A.J. (2006) Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. American Journal of Geriatric Psychiatry. 14(12):1004-11.
Murphy, G. G.; Shah, V.; Hell, J.W.; Silva, A.J. (2006) Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. American Journal of Geriatric Psychiatry. 14(12):1012-21.
Uchida, S.; Sakai, S.; Furuichi, T.; Hosoda, H.; Toyota, K.; Ishii, T.; Kitamoto, A.; Sekine, M.; Koike,K.; Masushige, S.; Murphy, G.; Silva, A.J.; Kida, S. (2006) Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Genes, Brain & Behavior. 5(1):96-106
Kushner, S. A.; Elgersma, Y.; Murphy, G. G.; Jaarsma, D.; van Woerden, G.; Hojjati, M. R.; Cui, Y.; LeBoutillier, J. C.; Marrone, D. F.; Choi, E. S.; De Zeeuw; Petit, T. L.; Pozzo-Miller, L. D.; Silva, A. J. (2005) Modulation of presynaptic plasticity and learning by the H-ras/ERK/synapsin I signaling pathway. Journal of Neuroscience. 25(42):9721-34.
Murphy, G. G.; Fedorov, N. B.; Giese, K. P.; Ohno, M.; Friedman, E.; Silva, A. J. (2004) Increased neuronal excitability, synaptic plasticity and learning in aged Kvb1.1 knockout mice. Current Biology 14(21):1907-15
Anagnostaras, S. G.; Murphy, G. G.; Mitchell, S L.; Rahnama, N. P.; Nathanson, N. M.; Silva, A. J. (2003) Selective Cognitive Dysfunction in Acetylcholine M1 Muscarinic Receptor Mutant Mice. Nature Neuroscience, 6(1): 51-58.
Costa, R. M.; Federov, N. B.; Kogan, J. H.; Murphy, G. G.; Stern, J.; Ohno, M.; Kucherlapati, R.; Jacks, T.; Silva, A. J. (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415 (6871): 526-530.
Murphy, G. G. and Glanzman, D. L. (1998) Learning and the sensorimotor synapse in Aplysia. Science, 281: 613
Murphy, G. G. and Glanzman, D. L. (1997) Mediation of Classical Conditioning in Aplysia californica by Long-Term Potentiation of Sensorimotor Synapses. Science, 278: 467-471.
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