Jack M. Parent M.D.
| 5021 Biomedical Sciences Research Building |
| Ann Arbor, MI 48109 |
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Our laboratory focuses on understanding the function of neural stem cells in the postnatal mammalian brain and their response to brain injury. We have shown that neurogenesis increases in the adult rat dentate gyrus and striatal subventricular zone (SVZ) in rodent models of epilepsy and stroke. During epileptogenesis, we find that many of the developing neurons migrate ectopically and integrate abnormally into existing neuronal networks. Stroke-induced neurogenesis appears to be more reparative, as we find that SVZ neuroblasts migrate to the injured striatum and replace damaged neurons.
We use a variety of techniques to study neonatal and adult neurogenesis in normal development and brain injury models. These include mitotic labeling, retroviral reporters/gene transfer, neurosphere stem cell and organotypic brain slice cultures, in vitro neuronal migration assays, in situ hybridization and immunohistochemical methods. An important direction of our work is to use knowledge of neural stem cell biology to develop novel therapeutic strategies for neurological diseases. Ongoing studies in our laboratory range from adult neurogenesis in zebrafish to human embryonic stem cell-derived neural progenitor transplantation in experimental stroke.
Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH. Dentate granule cell neurogenesis is induced by seizures and contributes to aberrant network plasticity in the adult hippocampus. J. Neurosci. 17:3727-3738, 1997.
Lowenstein DH, Parent JM. Brain, heal thyself. Science, 283:1126-1127, 1999.
Parent JM, Valentin VV, Lowenstein DH. Prolonged seizures increase neurogenesis in the rostral forebrain subventricular zone-olfactory bulb pathway of the adult rat. J. Neurosci. 22:3174-3188, 2002.
Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann. Neurol., 52:802-813, 2002.
Parent JM. Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist, 9:261-272, 2003.
Plane JM, Liu R, Wang TW, Silverstein FS, Parent JM. Neonatal hypoxic-ischemic injury increases subventricular zone neurogenesis in the mouse forebrain. Neurobiol. Dis., 16:585-595, 2004.
Wang TW, Zhang H, Parent JM. Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway. Development, 132:2721-2732. 2005.
Parent JM, von dem Bussche N, Lowenstein DH. Prolonged seizures recruit caudal subventricular zone glial progenitors into the injured hippocampus. Hippocampus, 16:321-328, 2006.
Wang TW, Stromberg GP, Whitney JT, Brower NW, Klymkowsky MW, Parent JM. Sox3 expression identifies neural progenitors in persistent neonatal and adult mouse forebrain germinative zones. J. Comp. Neurol., 497:88-100, 2006.
Parent JM, Elliott RC, Pleasure SJ, Barbaro NM, Lowenstein DH. Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Ann. Neurol., 59:81-91, 2006.
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