Margaret E. Gnegy Ph.D.
| 2220 Medical Sciences Research Building III, 0626 |
| Ann Arbor, MI 48109 |
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My research focuses on the role of signal transduction in the mechanism of action of amphetamine and the neurobiological adaptations that occur in the brain following repeated amphetamine. In addition, we are examining the effect of amphetamine on trafficking of the dopamine transporter. Finally, we are examining the interactions between nicotine and amphetamine on brain neurochemistry and behavior.
Chen, R., Zhang, M., Park, S., Gnegy, M.E.: C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SV mice. Pharmacol., Biochem., Behav. In press, 2007
Chen, R., Zhang, M., Park, S., Gnegy, M.E.: C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SV mice. Pharmacol., Biochem., Behav. In press, 2007
Johnson,L.A., Furman, C., Guptaroy, B., Gnegy, M.E., Rapid Delivery of the Dopamine Transporter upon Short-term Amphetamine Stimulation. Neuropharmacology, 49:750-758, 2005.
Johnson, L.A, Guptaroy, B., Lund, D., Shamban, S., Gnegy, M.E., Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. J Biol Chem. 280: 10914 ± 10919, 2005
Kantor, L., Zhang, M., Guptaroy, B., Park, Y.H. and Gnegy, M.E.: Repeated amphetamine couples norepinephrine transporter and calcium channel activities in PC12 cells. J. Pharmacol. Exp. Therap., 311:1044-1051, 2004.
Gnegy,M.E.; Khoshbouei,H.; Berg,K.; Javitch,J.A.; Clarke,W.; Zhang,M.; Galli,A., Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Mol. Pharmacol., 66:137-143, 2004.
Khoshbouei,H., Sen,N., Guptaroy,B., Johnson,L., Lund,D., Gnegy, M.E.,Galli,A., Javitch,J.A., N-terminal phosphorylation of the dopamine transporter is required for amphetamine-mediated efflux. Public Library of Science (PLOS), 2:387-393, 2004.
Gnegy,M.E., The effect of phosphorylation on amphetamine-mediated outward transport. Eur. J. Pharmacol. 479:83-91, 2003.
Park, Y.H., Kantor, L., Guptaroy, B., Wang, K.W.W. and Gnegy, M.E.,Repeated Amphetamine treatment induces Neurite Outgrowth and enhanced Amphetamine-mediated Dopamine release in Rat Pheochromocytoma cells (PC12 cells) via a Protein kinase C- and mitogen-activated protein kinase-dependent mechanism. J. Neurochem., 87: 1547-1557, 2003.
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