R Scott Turner M.D.,Ph.D.
| VA Medical Center GRECC (11G) 2399 |
| Ann Arbor, MI 48109 |
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The focus of research in my lab is to understand the molecular basis of Alzheimer’s disease (AD). We are studying the production and secretion of Ab peptides (the major component of amyloid plaques in AD brain) from amyloid precursor protein (APP) in a human neuronal cell culture model (NT2-N cells) and in transfected cell lines. We are interested in the regulation of APP metabolism and Ab secretion by APP-binding proteins such as X11a and the chaperone BiP/GRP78. Other pursuits include receptor-mediated regulation of APP metabolism in NT2-N cells by neurotransmitters. One goal of these projects is to suggest therapeutic strategies to delay the onset or slow progression of amyloid deposition, dementia, and AD.
King GD, Cherian K, Turner RS: X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein. Journal of Neurochemistry 88: 971-982, 2004.
Higdon R, Foster NL, Koeppe RA, DeCarli CS, Jagust WJ, Clark CM, Barbas NR, Arnold SE, Turner RS, Heidebrink JL, Minoshima S: A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging. Statistics in Medicine 23: 315-326, 2004.
King GD, Perez RG, Steinhilb ML, Gaut JR, Turner RS: X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: Mutational analysis of the YENPTY sequence. Neuroscience 120: 143-154, 2003.
Corcoran KA, Lu Y, Turner RS, Maren S: Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learning and Memory 9: 243-252, 2002.
Ho CS, Marinescu V, Steinhilb ML, Gaut JR, Turner RS, Stuenkel EL: Synergistic effects of Munc18a and X11 proteins on APP metabolism. Journal of Biological Chemistry 277: 27021-27028, 2002.
Steinhilb ML, Turner RS, Gaut JR: ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways. Journal of Neurochemistry 80: 1019-1028, 2002.
Hong M, Shah GV, Adams KA, Turner RS, Foster NL: Spontaneous intracranial hypotension causing reversible dementia. Neurology 58: 1285-1287, 2002.
Gau J-T, Steinhilb ML, Kao TC, D'Amato CJ, Gaut JR, Frey KA, Turner RS: Stable beta-secretase activity and presynaptic cholinergic function during progressive CNS amyloidogenesis in Tg2576 mice. American Journal of Pathology 160: 731-738, 2002.
Steinhilb ML, Turner RS, Gaut JR: The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-secretase. Journal of Biological Chemistry 276: 4476-4484, 2001.
Mueller HT, Borg JP, Margolis B, Turner RS: Modulation of amyloid precursor protein metabolism by X11alpha/mint-1. A deletion analysis of protein-protein interaction domains. Journal of Biological Chemistry 275: 39302-39306, 2000.
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