Richard Hume Ph.D.
| 3095 Natural Science Building 1048 |
| Ann Arbor, MI 48109 |
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The major interests of this lab are the molecular basis of synaptic transmission and synaptic development. Several recent studies have focused on glutamate receptors because glutamate is the dominant excitatory transmitter in mammalian brain. However, the majority of current work is focused on a second system that also mediates excitatory transmission in mammalian brain. ATP (adenosine triphosphate) is released from many synaptic terminals, and one action of this ATP is to gate a class of ion channels referred to as P2X receptors. Genes encoding seven different P2X receptors have recently been identified in mammals and members of the P2X gene family are widely expressed in the central and peripheral nervous system. The major goals of current research in this lab include: 1) To identify the molecular motifs of P2X receptors that account for ATP binding, channel gating and modulation of channel function. 2) To test the importance of P2X receptors in synaptic development. 3) To understand the role that P2X receptor mediated signaling plays in the mature brain.
Clyne, JD, LaPointe LD and Hume RI (2002) The role of histidine residues in modulation of the rat P2X2 purinoceptor by zinc and pH. Journal of Physiology 539:347-359
Clyne, J.D., Wang L-F, and Hume, R.I. (2002) Mutational analysis of the Conserved Cysteines of the Rat P2X2 purinoceptor. Journal of Neuroscience 22:3873-3880
Clyne, J.D., Brown, T and Hume, R.I. (2003) Expression level dependent changes in the properties of P2X2 receptors. Neuropharmacology 44:403-412
Nagaya N, Tittle RK, Saar N, Dellal SS and Hume RI (2005) An intersubunit zinc binding site in rat P2X2 receptors. Journal of Biological Chemistry 280:25982 - 25993
Cui WW, Low S, Hirata H, Saint-Amant L, Geisler R, Hume RI and Kuwada JY (2005) The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS. Journal of Neuroscience 25:6610 - 6620
Martinez-Pena y Valenzuela, I, Hume RI, Krejci E and Akaaboune, M (2005) In Vivo Regulation Of Acetylcholinesterase Insertion At The Neuromuscular Junction. J Biol. Chem. 280:31801 - 31808
Bruneau E, Macpherson P, Goldman DJ, Hume RI and Akaaboune M (2005) The Effect Of Agrin On Acetylcholine Receptor Dynamics At Aneural Clusters In Vitro. Developmental Biology 288:248-258
Bruneau E, Sutter D, Hume RI, and Akaaboune M. (2005) Identification of Nicotinic Acetylcholine Receptor Recycling and its Role in Maintaining Receptor Density at the Neuromuscular Junction in vivo. Journal of Neuroscience 25:9949 ‚ 9959
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