Rudy J. Richardson ScD
| M7525 School of Public Health II 2029 |
| Ann Arbor, MI 48109 |
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The goal of the Richardson lab is to understand the neurotoxicology of organophosphorus (OP) compounds and the physiological and pathogenic functions of their protein targets, e.g., neuropathy target esterase (NTE). Approaches within the lab include kinetics and protein mass spectrometry. Through collaborations, we also use biochemical engineering, bioinformatics, computational molecular modeling, population and molecular genetics, molecular epidemiology, nanotechnology, network theory, spectroscopy (e.g., circular dichroism), and x-ray crystallography.
Rainier, S., Bui, M., Mark, E., Thomas, D., Tokarz, D., Ming, L., Delaney, C., Richardson, R.J. Albers, J.W., Matsunami, N., Stevens, J., Coon, H., Leppert, M., and Fink, J.K. (2008). Neuropathy target esterase gene mutations cause motor neuron disease. Am. J. Hum. Genet. 82, 780-785.
Kohli, N., Srivastava, D., Sun, J., Richardson, R.J., Lee, I., and Worden, R.M. Nanostructured biosensor for measuring neuropathy target esterase activity. (2007). Anal. Chem. 79, 5196-5203.
Makhaeva, G.F., Malygin, V.V., Strakhova, N.N., Sigolaeva, L.V. Sokolovskaya, L.G., Eremenko, A.V., Kurochkin, I.N., and Richardson, R.J. (2007). Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: Review of progress. Hum. Exp. Toxicol. 26, 273-282.
Wijeyesakere, S.J., Richardson, R.J., and Stuckey, J.A. (2007). Modeling the tertiary structure of the patatin domain of neuropathy target esterase. Protein J. 26, 165-172.
Kropp, T.J., and Richardson, R.J. (2007). Mechanism of aging of mipafox-inhibited butyrylcholinesterase. Chem. Res. Toxicol. 20, 504-510.
Kropp, T.J., and Richardson, R.J. (2006). Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct. Chem. Res. Toxicol. 19, 334-339.
Sokolovskaya, L.G., Sigolaeva, L.V., Eremenko, A.V., Gachok, I.V., Makhaeva, G.F., Strakhova, N.N., Malygin, V.V., Richardson, R.J., and Kurochkin, I.N. (2005). Improved electrochemical analysis of neuropathy target esterase activity by a tyrosinase carbon paste electrode modified by 1-methoxyphenazine methosulfate. Biotechnol. Lett. 27, 1211-1218.
Makhaeva G.F., Malygin V.V., Aksinenko A.Y., Sokolov, V.B., Strakhova, N.N., Rasdolsky, A.N., Richardson, R.J., and Martynov, I.V. (2005). Fluorinated 1-aminophosphonates--A new type of irreversible inhibitors of serine hydrolases. Doklady Russ. Acad. Sci. (Biochem., Biophys.) 400, 92-95 [English]. Doklady Akademii Nauk 400, 831-835 [Russian].
Kropp, T.J., Glynn, P., and Richardson, R.J. (2004). The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible proton loss. Biochemistry 43, 3716-3722.
Doorn, J.A., Thompson, C.M., Christner, R.B., and Richardson, R.J. (2003). Stereoselective interaction of Torpedo californica acetylcholinesterase by isomalathion: Inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms. Chem. Res. Toxicol. 16, 958-965.
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