Ralph Lydic Ph.D.
Bert La Du Professor of Anesthesiology
| 7433 Medical Science I 0615 |
| Ann Arbor, MI 48109 |
The National Heart, Lung, and Blood Institute of the National Institutes of Health funds Dr. Lydic's laboratory. The goals of his research programs are to elucidate the mechanisms by which sleep, opioids, and volatile anesthetics depress breathing and arousal. The evolutionary perspective, and current data, supports the view that neurons generating sleep and wakefulness preferentially modulate the ability of opioids, hypnotics, and anesthetics to obtund wakefulness. This concept underlies work in Dr. Lydic's laboratory characterizing the neurochemical and signal transduction processes through which cholinergic neurons modulate sleep, arousal, and autonomic control. Recent work has shown that adenosine and nitric oxide modulate pontine acetylcholine release and arousal. A second research program is characterizing the effects of opioids on cholinergic neurotransmission. These studies aim to understand the cellular and molecular mechanisms by which opioids inhibit cholinergic neurotransmission and disrupt sleep and breathing. Both of these research programs encourage an active interaction between basic and clinical investigators.
- Gauthier EA, Guzick SE, Brummett CM, Baghdoyan HA, Lydic R.Buprenorphine disrupts sleep and decreases adenosin concentration in sleep-regulating brain regions of Sprague Dawley rat. Anesthesiology;115:743-53, 2011 Oct.[PubMed]
- Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R.Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.Anesthesiology;115:836-43, 2011 Oct.[PubMed]
- Lichtor JL, Lydic R.Volatile anesthesia does not satisfy rapid eye movement sleep debt (Comment on Anesthesiology 2011 Oct 115:702-12). Anesthesiology;115:683-4, 2011 Oct.[PubMed]
- Watson CJ, Lydic R, Baghdoyan HA.Sleep duration varies as a function of flutamate and GABA in rat pontine reticular formation. J Neurochem;118:571-80, 2011 Aug.[PubMed]
- Vanini G, Wathen BL, Lydic R, Baghdoyan HA.Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep. J Neurosci;16:2649-56, 2011 Feb.[PubMed]
- Brown EN, Lydic R, Schiff ND.General anesthesia, sleep, and coma. N Engl J Med;363:2638-50, 2010 Dec.[PubMed]
- Watson CJ, Baghdoyan HA, Lydic R.Neuropharmacology of sleep and wakefulness.Sleep Med Clin;5:513-28, 2010 Dec.[PubMed]
- Muncey AR, Saulles AR, Koch LG, Britton SL, Baghdoyan HA, Lydic R.Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in a rat model of metabolic syndrome. Anesthesiology;113:1176-85, 2010 Nov.[PubMed]
- Brevig HN, Watson CJ, Lydic R, Baghdoyan HA.Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness. Sleep;33:1285-93, 2010 Oct.[PubMed]
- Flint R, Chang T, Lydic R, Baghdoyan H.GABA (A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness. J Neurosci;30:12301-09, 2010 Sep.[PubMed]
- Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R.Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block. Reg Anesth Pain Med;35:427-31, 2010 Sep.[PubMed]
- Hambrecht-Wiedbusch VS, Gauthier EA, Baghdoyan HA, Lydic R.Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG Power and Acetylcholine release in rat pontine reticular formation. Sleep;33:909-18, 2010 Jul.[PubMed]
- Watson SL, Watson CJ, Baghdoyan HA, Lydic R.Thermal nociception is decreased by hypocretin-1 and an adenosin A(1) receptor agonist microinjected into the pontine reticular formation of Sprague Dawley Rat. J Pain;11:535-44, 2010 Jun.[PubMed]
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