Sid Gilman M.D.
| 300 North Ingalls St. 3D15 |
| Ann Arbor, MI 48109 |
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I am investigating the neurochemical basis of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)using positron emission tomography (PET) with [11C]DTBZ and [11C]PMP.
Additional investigations are focused on the post-ganglionic sympathetic innervation of the heart in PD, DLB, MSA, and progressive supranuclear palsy (PSP) and dopaminergic innervation of the striatum. These studies utilize PET with [11C]DTBZ and [11C]HED.
Another set of investigations concerns Alzheimer's disease, testing the hypothesis that in the early stages of the disease, the larger the area of cortical hypometabolism the faster the rate of progression of the disease. This study utilizes PET with [18F]FDG, [11C]DTBZ, and [11C]PIB.
In studies with Cortex Pharmaceuticals, I am studying the effects of an Ampakine upon recent memory in patients with Alzheimer's disease, studying cerebral blood flow changes during neuropsychological testing using [15O)H2O.
In studies with Elan and Wyeth pharmaceutical companies, I am serving as Chair of the Safety Monitoring Committee for passive immunotherapy for Alzheimer's disease.
Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Boada Rovira M, Forette F, Orgogozo J-M. Clinical effects of A-beta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005;64:1553-1562.
Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M. Effects of A-beta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 2005;64:1563-1572.
Gilman S, Koeppe RA, Little R, An H, Junck L, Giordani B, Persad C, Heumann M, Wernette K. Differentiation of Alzheimerís disease from dementia with Lewy bodies utilizing [18F]fluorodeoxyglucose and neuropsychological testing. Exp Neurol 2005;191:S95-S103.
Wenning GK, Tison F, Seppi K, Sampaio C, Diem A, Yekhlef F, Ghorayeb I, Ory F, Galitzky M, Scaravilli T, Bozi M, Colosimo C, Gilman S, Shults CW, Quinn NP, Rascol O, Poewe W, and the European MSA Study Group. Development and validation of the unified multiple system atrophy rating scale (UMSARS). Mov Disord 2004;19:1391-1402.
Gilman S, Koeppe RA, Little R, An H, Junck L, Giordani B, Persad C, Heumann M, Wernette K. Striatal monoamine terminals in Lewy body dementia and Alzheimerís disease. Ann Neurol 2004;55:774-780.
Orgogozo J-M, Gilman S, Dartigues J-F, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman S, Michel BF, Boada M, Frank A, Hock C. Subacute Meningoencephalitis in a subset of patients with AD after A42 immunization. Neurology 2003;61:46-54.
Gilman S, Koeppe RA, Chervin R, Consens F, Little R, An H, Junck L, Heumann M. Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA. Neurology 2003;61:35-39.
Gilman S, Koeppe RA, Chervin R, Consens F, Little R, An H, Junck L, Heumann M. REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA. Neurology 2003;61:29-34.
Berent S, Giordani B, Gilman S, Trask CL, Little RJA, Johanns JR, Junck L, Kluin KJ, Heumann M, Koeppe RA. Patterns of neuropsychological performance in multiple system atrophy compared to sporadic and hereditary olivopontocerebellar atrophy. Brain and Cognition 2003;50:194-206.
Gilman S. Joint position sense and vibration sense: anatomical organisation and assessment. J Neurol Neurosurg Psychiatry 2002;73:473-477.
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