Richard Altschuler Ph.D.
| HR5012 Kresge Hearing Research Institute, 0506 |
| Ann Arbor, MI 48109 |
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A major research area is the study of activity dependent plasticity in the auditory pathways. We examine changes in expression and localization of amino acid neurotransmitters and their receptors following deafness, the impact on processing as well as "re-adjustment" following re-introduction of activity with cochlear prostheses.
In the inner ear we study interventions to enhance auditory nerve survival following deafness, to induce regrowth of its processes as well as using stem cells to replace lost auditory nerve.
We are studying the stress response pathways that play a role in protection, repair and recovery from stresses to the inner ear such as noise overstimulation and ototoxic drugs and how changes with aging may contribute to age-related hearing loss.
Buras, ED, Holt, AG, Griffith, RD, Asako,M, Altschuler, RA, Changes in glycine immunoreactivity in the rat SOC following deafness, J. Comp. Neurol., 494:179-89, 2006.
Holt AG, , Asako M, Duncan RK, Lomax CA, Juiz JM, Altschuler RA, Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus, Hearing Res. 216-217:146-53, 2006
Fairfield, DA, Margaret I. Lomax, MI, Gary A. Dootz, GA, Chen, S, Galecki, TA, Benjamin, IJ, David F. Dolan, DF, Altschuler, RA, Heat shock factor 1 (Hsf1) deficient mice exhibit decreased recovery of hearing following noise overstimulation, J. Neurosci Res. 81:589-596, 2005
Holt AG, Asako A, Lomax, CA, MacDonald JW, Tong L, Lomax MI, Altschuler, RA, Deafness related plasticity in the inferior colliculus: Gene expression profiling following removal of peripheral activity, J. Neurochem, 93:1069-86, 2005
Tong L, Altschuler RA, Holt AG, Tyrosine hydroxylase in the rat auditory midbrain: Distribution and changes following deafness, Hearing Res. 206:28-41, 2005
Cho Y, Gong T-W, Kanicki A, Altschuler RA & Lomax MI, Noise overstimulation induces early immediate genes in the rat cochlea, Molecular Brain Research, 130:134-148, 2004
Fairfield, D.A., Kanicki, A.C., Lomax, M.I., Altschuler, R.A., Induction of heat shock protein 32 (Hsp32) in the rat cochlea following hyperthermia. Hear. Res. 188, 1-11. 2004
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