Susan E Shore Ph.D.
| 6016 Kresge Hearing Research Institute 0506 |
| Ann Arbor, MI 48109 |
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The objectives of my laboratory are to study the role of neural connections from other parts of the brain to the cochlear nucleus. A strong emphasis of our studies are two major projection systems: the somatosensory innervation to the external regions of the cochlear nucleus, and descending connections from other auditory structures to core regions of the cochlear nucleus. In addition to the normal innervation, we also study changes in these pathways after various forms of hearing loss, and their possible roles in tinnitus, loudness recruitment and central auditory processing.
We use tract-tracing and immunohistochemical methods to study neural connections and single and multi unit neurophysiology to study the responses of neurons to sounds. The implementation of multichannel recording and drug-delivery electrodes expedites our studies of single cell responses. Lesion studies and neuropharmacology are used to assess the role of extracochlear pathways in sound coding.
Shore, S.E. El Kashlan, H and Lu, J. Effects of trigeminal gangion stimulation on unit activity in the ventral cochlear nucleus of the guinea pig. Neuroscience, 119 (4): 1085 - 1101, 2003
Bledsoe, S.C., Shore, S.E. and Guitton, M.J. Spatial representation of corticofugal input in the inferior colliculus: A multicontact silicon probe approach. Experimental Brain Research, 153(4):530-42, 2003.
Shore SE., Sumner, C., Bledsoe SC, and Lu, J. Binaural integration in the guinea pig ventral cochlear nucleus. Experimental Brain Research, 221:427-435. 2003.
Shore SE, Clarke S, Rouiller EM.Central auditory processing: integration with other systems. Exp Brain Research, 153(4):403-4, 2003.
El-Kashlan, H and Shore, SE. Effects of trigeminal ganglion stimulation on 2-DG activity in the auditory pathway. Hearing Research, 89 (1-2), 25-30, 2004.
Shore, S.E., Lu J. The dorsal cochlear nucleus integrates acoustic to somatosensory inputs. Soc. for Neuroscience Abstr. Nov, 2003.
Shore S.E.,Vass, Z., Wys, N., Altschuler, R.A.: The trigeminal ganglion innervates the auditory brainstem. J. Comp. Neurol. 419:271-285, 2000
Vass, Z., Shore, S.E., Nuttall, A.L., Miller, J.M.: Endolymphatic hydrops reduces trigeminal innervation to inner ear vasculature. Experimental Neurology, 151:241-248, 1998
Vass, Z., Shore, S.E., Nuttall, A.L. Miller, J.M.: Direct evidence of trigeminal innervation of the cochlear blood vessels. Neuroscience, 84:559-567, 1998
Shore, S.E.: Influence of centrifugal pathways on forward masking of ventral cochlear nucleus neurons. J. Acoust. Soc. Am. 104:378-389, 1998
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