Jon-Kar Zubieta M.D.,Ph.D.
| 1062 Mental Health Research Institute 0720 |
| Ann Arbor, MI 48109 |
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This laboratory utilizes imaging techniques (positron emission tomography, single photon emission computed tomograpy, magnetic resonance imaging and spectroscopy) to explore aspects of brain neurochemistry, function and anatomy as they relate to the pathophysiology of mood disorders and substance abuse. In the area of mood disorders and affective regulation they are studying the role of the opioid system in Major Depression. This system is involved in responses to stress, and in hedonic and reward functions. In a related theme, they are exploring gender differences in the function of the endogenous opioid system during a tonic pain challenge, under double-blind, placebo-controlled conditions. The involvement of the opioid system in substance dependence and withdrawal is being explored in two parallel projects. Other ongoing studies include the study of brain functional responses (regional cerebral blood flow and regional metabolic rate of glucose) to the administration of nicotine. Finally, the regulation of cholinergic synaptic contacts by long-term estrogen replacement in postmenopausal women is being explored.
Zubieta, J.K., Gorelick, D., Stauffer, R., Dannals, R.F., Ravert, H.T., Frost, J.J.: Increased mu-opioid receptor availability in cocaine abuse and its association with craving. Nature Med. 2: 1225-9, 1996.
Smith, J.S., Zubieta, J.K., Price, J.C., Madar, I., Flesher, J., Lever, J.R., Kinter, C.M., Dannals, R.F. and Frost, J.J.: Quantification of delta opioid receptors in human brain with N1'([11C]Methyl)naltrindole and positron emission tomography. J. Cereb. Blood Flow Metab. 19:956-966, 1999.
Guthrie, S.K., Zubieta, J.K., Ohl, L., Ni, L., Koeppe, R.A., Minoshima, S., Domino, E.F.: Arterial/venous plasma nicotine concentrations following nicotine nasal spray. European Journal of Clinical Pharmacology 55(9): 639-43, 1999.
Taylor, S.F., Koeppe, R.A., Tandon, R., Zubieta, J.K., Frey, K.A.: In vivo measurement of the vesicular monoamine transporter in schizophrenia. Neuropsychopharmacology. 23:667-75, 2000
Domino, E.F., Minoshima, S., Guthrie, S., Ohl, L., Ni, L., Koeppe, R.A., Zubieta, J.K.: Nicotine effects on regional cerebral blood flow in awake, resting tobacco smokers. Synapse. 38:313-21, 2000
Zubieta, J.K., Taylor, S.F., Huguelet, P., Koeppe, R.A., Kilbourn, M.R., Frey, K.A.: Vesicular monoamine transporter concentrations in bipolar disorder type I, schizophrenia, and healthy subjects. Biological Psychiatry. 49:110-6, 2001
Smith, Y.R., Minoshima, S., Kuhl, D.E., Zubieta, J.K.: Effects of long-term hormone therapy on cholinergic synaptic concentrations in healthy postmenopausal women. Journal of Clinical Endocrinology & Metabolism. 86:679-84, 2001
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