Shelley Batts

Batts, S.A. et al. 2007. Ototoxicity Results in Notch Signaling Activation and Jag1 Up-Regulation. Association for Research in Otolaryngology (poster).

Batts, S. A. and Y. Raphael. Transdifferentiation and its applicability for inner ear therapy. Hearing Research. Oct 2006.

M. Izumikawa, S.A. Batts, K.A. Abrashkin, D.L. Swiderski, D. Dolan, Y. Raphael. 2005. Auditory hair cell replacement and hearing improvement after Math1 gene therapy in mature deafened guinea pigs. Association for Research in Otolaryngology (Poster).

S.A. Batts, M. Izumikawa, M. Crumling, Y. Raphael. 2005. Neuronal growth towards regenerated hair cells following Math1 gene therpy in deafened guinea pigs. Association for Research in Otolaryngology (Abstract and symposia talk).

M. Izumikawa, Y. Raphael, et al. 2005. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nature Medicine. Advance online publication Feb 15, 2005.

	Shelley A Batts B.S.
	Neuroscience Program
	Otolaryngology
	Advisor: Dr. Yehoash Raphael
	9220B MSRB III 0648
	(734) 615-6983
	Undergraduate Institution: New College of Florida
	Undergraduate Major: Biochemistry
	shelleba@umich.edu
	My website



	Hair cell loss in the organ of Corti causes permanent and irreversible hearing impairment, as mammals are unable to replace hair cells once destroyed. This is in contrast to birds and reptiles, who can spontaneously regenerate new hair cells in reponse to damage. Understanding the difference between these two species' ability to restore their hearing is the major question of our lab (Y. Raphael lab). Atoh1, the mouse homolog of the gene atonal, generates new hair cells in mammals when expressed in the cochlea by an adenovirus (Izumikawa et al, 2005). My research currently is focused on characterizing hair cells regenerated using viral and non-viral methods, as well as the underlying changes that occur in cell signaling cascades during deafness and regeneration. Understanding how cells signal to each other, and how these signals differ in birds vs. mammals, may hold the key to inducing hair cell regeneration.

	Batts, S.A. et al. 2007. Ototoxicity Results in Notch Signaling Activation and Jag1 Up-Regulation. Association for Research in Otolaryngology (poster). Batts, S. A. and Y. Raphael. Transdifferentiation and its applicability for inner ear therapy. Hearing Research. Oct 2006. M. Izumikawa, S.A. Batts, K.A. Abrashkin, D.L. Swiderski, D. Dolan, Y. Raphael. 2005. Auditory hair cell replacement and hearing improvement after Math1 gene therapy in mature deafened guinea pigs. Association for Research in Otolaryngology (Poster). S.A. Batts, M. Izumikawa, M. Crumling, Y. Raphael. 2005. Neuronal growth towards regenerated hair cells following Math1 gene therpy in deafened guinea pigs. Association for Research in Otolaryngology (Abstract and symposia talk). M. Izumikawa, Y. Raphael, et al. 2005. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nature Medicine. Advance online publication Feb 15, 2005.
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