Welcome to the RNA and Single Molecule Analysis Group of Nils Walter!

Non-coding ribonucleic acid (RNA) has recently been found to be the key component, often capable of enzymatic action, in a multitude of essential cellular processes, such as gene regulation - through processes including RNA interference and riboswitching -, translation, and splicing. RNA thus is increasingly finding important applications in modern biotechnology and medicine, for example as biosensor and gene therapeutic agent. Just look at recent issues of Science  and Nature .

We explore the world of such catalytic RNAs, or "ribozymes", as well as other non-protein coding RNAs by using single-molecule and bulk-solution biochemical and biophysical tools. Which means that we work on fascinating biological catalysts at the interface of Chemistry, Biology, and Physics.

Single-molecule techniques are now being made more widely available to those who are not experts in the field. See the article that appeared in U.S. News concerning the opening of University of Michigan's Single Molecule Analysis in Real Time (SMART) Center.

Want to know more about us? Use the links to your left!

Please also check out the following press releases on our work:
Single Molecule Enzymology and Biosensing
RNA and Water
Chemical Bonding Center for Molecular Cybernetics
And our Single Molecule Center website

Any questions? Then contact Nils Walter at nwalter@umich.edu

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