WELCOME TO THE RUOTOLO RESEARCH GROUP

Our research is focused on developing new tools and technologies aimed at determining the 3D structure and stability of multi-protein assemblies important in biology and medicine.

Most of our technology development centers on ion mobility-mass spectrometry (IM-MS) - an approach that can measure both the mass and the size of heterogeneous protein complexes at low levels in the presence of complex mixtures. Our long-term goal is to develop new, innovative approaches that integrate IM-MS with other structural biology tools and solve some truly challenging problems in the field of structural genomics.

Research in our group is broken up into five main areas (shown graphically, to the right).

 

 

 

 

BUILDING UNIVERSAL STRATEGIES FOR STABILIZING PROTEIN COMPLEX STRUCTURE IN THE ABSENCE OF BULK SOLVENT

HIGH-THROUGHPUT PROTEIN-LIGAND SCREENING

APPLICATIONS OF ION MOBILITY-MASS SPECTROMETRY TO DISEASE-ASSOCIATED MULTI-PROTEIN SYSTEMS

BUILDING ARCHITECTUAL MODELS OF MULTI-PROTEIN COMPLEXES BASED ON ION MOBILITY-MASS SPECTROMETRY DATASETS

GROUP INSTRUMENTATION