Supplementary datasets for

Xu and Zhang (2014) Why human disease-associated residues appear as the wild-type in other species: genome-scale structural evidence for the compensation hypothesis. Published

readme.pdf Readme file for the datasets

saap.list Single nucleotide polymorphsim (SAAP) list (Uniprot ID, Position, Reference Residue, Polymorphism Residue, Minor allele frequency)

saap.ali Protein sequence and structure alignment containing SAAPs

saap_maf001.ali Protein sequence and structure alignment containing SAAPs with MAF >= 0.01

dar.list Disease-associate residue list (Uniprot ID, Position, Wild type residue, Disease-associate residue (DAR))

rg-DAR.ali Alignment of human protein sequence, structure and ortholog containing rg-DARs

wt-DAR.ali Alignment of human protein sequence, structure and ortholog containing wt-DARs

compensated_wt-DAR.list List of wt-DARs with potential compensatory residues detected

compensated_wt-DAR.ali Alignment of human protein, structure and ortholog containing wt-DARs with potential compensatory residues detected

compensated_wt-DAR.ali.seqid60 Alignment of human protein, non-redundant structure and ortholog containing wt-DARs with potential compensatory residues detected

noncompensated_wt-DAR.ali Alignment of human protein, structure and ortholog containing wt-DARs with non-compensatory residues detected

comp_noncomp_equal.tar.gz Alignment of human protein, structure and ortholog containing wt-DARs with equal number of compensatory and non-compensatory residues detected

DARLvsWTRL.xlsx Detecting compensation specificity

pdb.tar.gz All native protein structures and models used in the paper

pdbdist.tar.gz Minimum distances between non-hydrogen atoms of residues in the structures