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The paper Redox Economy in Organic Synthesis was cited in in this paper in relation to the synthesis of molecule 76 from molecule 80.1 The purpose of this paper is to provide information on completing organic synthesis by not using redox reactions if they do not form the molecular skeleton or induce a specific stereochemistry. This paper was cited, because it provided information on an isohypsic isomerization reaction that could have been a viable method to form the THF ring and convert 80 to 76 in a single step. This reaction would not have any redox steps and is depicted below. The initially proposed reaction utilized O2 to add an alcohol to one of the double bonds. This part worked as expected, but it was not possible for dehydration to occur and form molecule 76. Therefore, this reaction failed. Due to this failure, the reaction was instead completed by a subsequent elimination step with LiBr and Li2CO3. Ma, L.; Chen, W.; Seidel, D. J. Am. Chem. Soc. 2012, 134, 15305-15308. Richers, M. T.; Deb, I.; Platonova, A. Y.; Zhang, C.; Seidel, D. Synthesis, 2013, 45, 1730-1748. Zhang, C.; Seidel, D. J. Am. Chem. Soc. 2010, 132, 1798-1799.
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