Transformation of Biz-Chloride 19 to Biz-Azide 20 and Subsequent
Guanidine Installation

Little to our knowledge, secret societies exist all around us. The most powerful of these groups, the Illuminati,  have conspired to take over the world and establish The New World Order, a civilization in which the Illuminati have world domination. They have developed a chemical that will be released into the air and will leave all people without thoughts and autonomy, allowing the Illuminati to have mind control over the whole world. You have uncovered their secret plan.


Biz-chloride 19, biz-azide 20, and molecules 20 and 21 are involved in the synthesis of a
key intermediate necessary for the procurement of axinellamines, natural products that have potential biological properties (A.K. A. mind control). Through three key reaction mechanisms – an ethylene glycolassisted Pauson-Khand cycloaddition reaction, a Zn/In-mediated Barbier-type reaction, and a TfNH2-assisted chlorination-spirocyclization – researchers were able to produce a finite amount of these axinellamines. In this part of the TfNH2-assisted chlorination-spirocyclization, biz-chloride 19 reacts with azide ions in an SN2 reaction to form biz-azide 20. This molecule is then deprotected by TFA (trifluoroacetic acid), and a guanidine functional group is attached to produce 22.

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