Publications

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Recent Publications:

Fluorescent Nano-PEBBLE Sensors for the Real-Time Measurement of Glucose Inside Living Cells, H. Xu, J.W. Aylott and R. Kopelman, Analyst 127, 1471-1477 (2002).

Ion Concentrations in Live Cells from Highly Selective Ion Correlations Fluorescent Nano-Sensors for Sodium, M. Brasuel, R. Kopelman, I. Kasman, T.J. Miller and M.A. Philbert, Proceedings of IEEE 1, 288-292 (2002).

Spatially and Temporally Resolved Studies of Convection-Less Photobleaching Kinetics: Line Trap, S.H. Park, H. Peng, S. Parus, H. Taitelbaum and R. Kopelman, M.El-Sayed, G.R. Fleming and S. Colson, Eds., G. Wilse Robinson Festschrift, J. Phys. Chem. 106, 7586-7592 (2002).

Optical Trapping Near Resonance Absorption, R.R. Agayan, C.F. Schmidt, F. Gittes and R. Kopelman, Appl. Opt. 41, 2318-2327 (2002).

Cooking with Nanoparticles: A Simple Method of Forming Roll, Pancake, and Breaded Polystyrene Microparticles, J.N. Anker, T.D. Horvath and R. Kopelman, European Cells and Materials 3 (Suppl. 2), 95-97 (2002).

Optochemical Nanosensors for Noninvasive Cellular Analysis, S.L.R. Barker, H.A. Clark and R. Kopelman in Biomedical Diagnostics Science and Technology, W.T. Law, N. Akmall and A.M. Usmani, Eds., Chapter 7, 139-164, Marcel Dekker, Inc. (New York), 2002.  [Invited Book Chapter]

PEBBLE Nanosensors for Real Time Intracellular Chemical Imaging, M. Brasuel, R. Kopelman, M.A. Philbert, J.W. Aylott, H. Clark, I. Kasman, M. King, E. Monson, J. Sumner, H. Xu, M. Hoover, T.J. Miller and R. Tjalkens, F. Ligler and C. Rowe-Tait, Eds., in Optical Biosensors: Present and Future, Elsevier (Amsterdam), 497-536 (2002).    [Invited book chapter]

Integrated Organic Light Emitting Devices/Fluorescence-Based Chemical Sensor Arrays, V. Savvate’ev, Z. Chen-Esterlit, J.W. Aylott, B. Choudhury, C.H. Kim, L. Zou, J.H. Friedl, R. Shinar, J. Shinar and R. Kopelman, Appl. Phys. Lett. 81, 4652-54 (2002).

A Fluorescent PEBBLE Nanosensor for Intracellular Free Zinc, J. Sumner, J.W. Aylott, E. Monson and R. Kopelman, Analyst 127, 11-16 (2002).

Preparation and Characterization of Poly (ethylene glycol)-Coated Stöber Silica Nanoparticles for Biomedical Applications, H. Xu, F. Yan, E. Monson, W. Tang, R. Kopelman, R. Schneider and M. Philbert, SPIE (International Society of Photonic Engineering) Proc. 4626, 383-393 (2002).

Optical Fiberless Sensors, R. Kopelman, H. Clark and M. Philbert, U.S. Patent #6,379,955, April 30, 2002.

Use of Steady-State Fluorescence Anisotropy with Pebble Nanosensors for Chemical Analysis, T. Horvath, E. Monson, J. Sumner, H. Xu and R. Kopelman, SPIE (International Society of Photonic Engineering) Proc., 4626, 482-492 (2002).

Development of a Hydroxyl Radical Nanoprobe, M. King and R. Kopelman, SPIE (International Society of Photonic Engineering) Proc., 4625, 70-73 (2002).

Magnetically Modulated Chemical Sensors for Background Rejection, J. Anker and R. Kopelman, U. S. Patent (submitted December 17, 2001).

Targeted Fiberless Photonic Effectors, R. Kopelman, J. Aylott, H. Clark, E. Monson and M. Philbert, U.S. Patent (resubmitted November 2001), Serial No.: 09/336,314.

Production, Characteristics and Applications of Fluorescent PEBBLE Nano-Sensors: Potassium, Oxygen, Calcium and pH Imaging Inside Live Cells, M. Brasuel, J.W. Aylott, H. Clark, H. Xu, R. Kopelman M. Hoyer, T.J. Miller, R. Tjalkens and M. Philbert, Review, S. Barker, Ed., in Sensors and Materials, (M.Y.U. KK, Tokyo, Japan), Vol. 14,  pp. 309-338 (2002).  [Invited Review]

Wireless Deep Tissue Light Sources: Scalable Organic Light Emitting Devices, M. Philbert, Z. Chen, J. Kanicki and R. Kopelman, U.S. Patent (Submitted July 29, 2002).

PEBBLE Nanosensors for in vitro Bioanalysis, E. Monson, M. Brasuel, M. Philbert and R. Kopelman, T. Vo-Dinh, Ed., in Biomedical Photonics Handbook, Ch. 59, 1-14, CRC Press (2003).

Production of Singlet Oxygen by Ru(dpp(SO₃)₂)₃ Incorporated in Polyacrylamide PEBBLEs, M.J. Moreno, E. Monson, R.G. Reddy, A. Rehemtulla, B.D. Ross, M. Philbert, R.J. Schneider and R. Kopelman, Sensors and Actuators B: Chemical, 90, 82-89 (2003).

Development of a Hydroxyl Radical Ratiometric Nanoprobe, M. King and R. Kopelman, Sensors and Actuators B: Chemical 90, 76-81 (2003).

Optical Sensors for the Detection of Nitric Oxide, R. Kopelman, H. Clark and S. Barker, U.S. Patent #6,636,652, October 21, 2003.

Magnetically Modulated Optical Nanoprobes, J.N. Anker and R. Kopelman, Applied Physics Letters 82, 1102-1104 (2003).

Anomalous Growth of the Depletion Zone in the Photobleaching Trapping Reaction, S.H. Park, H. Peng, R. Kopelman, P. Argyrakis and H. Taitelbaum, Phys. Rev. E. Rapid Communication, 67, 060103(R)-1-060103(R)-4 (2003).

Aspherical MagMOONs (Magnetically Modulated Optical Nanoprobes), J. Anker, C. Behrend and R. Kopelman, J. App. Phys. 93, 6698-6700 (2003).

Room-Temperature Preparation and Characterization of Poly (ethylene glycol)-Coated Silica Nanoparticles for Biomedical Applications, H. Xu, F. Yan, E.E. Monson and R. Kopelman, J. Biomed. Mat. Res. 66A(4), 870-879 (2003).

Ratiometric Optical PEBBLE Nanosensors for Real-Time Magnesium Ions Concentrations Inside Viable Cells, E.J. Park, M. Brasuel, C. Behrend, M.A. Philbert and R. Kopelman, Anal. Chem. 75, 3784-3791 (2003).

Development and Biological Application of Liquid Polymer PEBBLEs for Cl^-, M.G. Brasuel, T.J. Miller, R. Kopelman and M.A. Philbert, Analyst 128, 1262-1267 (2003).

The Embedding of meta-Tetra (hydroxyphenyl) Chlorin into Silica Nanoparticle Platforms for Photodynamic Therapy and Their Singlet Oxygen Production and pH Dependent Optical Properties, F. Yan and R. Kopelman, Photochemistry and Photobiology 78, 587-591 (2003).

Dynamics of the Depletion Zone at a Finite-Sized Imperfect Trap in 2D: Photobleaching Experiments and Simulations, H. Peng, S.H. Park, P. Argyrakis, H. Taitelbaum and R. Kopelman, Phys. Rev. E 68, 061102-1-061102-10 (2003).

Aspherical Magnetically Modulated Optical Nanoprobes (MagMOONs), J. Anker and R. Kopelman, Virtual Journal of Nanoscale Science, http://gps.aip.org/journals/doc VIRT01 (2003).

A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging Using MRI, B.A. Moffat, G.R. Reddy, P. McConville, D.E. Hall, T.L. Chenevert, R. Kopelman, M. Philbert, R. Weissleder, A. Rehemtulla and B.D. Ross, Mol. Imaging 2, 324-332 (2003).

Optical Manipulation of Metal-Silica Hybrid Nanoparticles, R.R. Agayan, T. Horvath, B.H. McNaughton, J.N. Anker and R. Kopelman, Proc. SPIE (International Society of Photonic Engineering) Proc. 5514, 502-513 (2004).

Poly (Decyl methacrylate)-based Fluorescent PEBBLE Swarm Nanosensors for Measuring Dissolved Oxygen in Biosamples, Y. Cao, Y.-E. Koo and R. Kopelman, Analyst, 129, 745-750 (2004).

Optochemical Nanosensor PEBBLEs: Photonic Explorers for Bioanalysis with Biologically Localized Embedding, S.M. Buck, Y.-E. L. Koo, E. Park, H. Xu, M.A. Philbert, M.A. Brasuel and R. Kopelman, edited by R. Zenobi and F. Regnier, in Current Opinion in Chemical Biology 2004 8, 540-546 (2004).

Fluorescent PEBBLE Nanosensors and Nanoexplorers for Real-Time Intracellular and Biomedical Applications, H. Xu, S.M Buck, R. Kopelman, M.A. Philbert, M. Brasuel, E. Monson, C. Behrend, B. Ross, A. Rehemtulla and Y.-E. L. Koo in Topics in Fluorescence Spectroscopy, Vol. 10, C.D. Geddes and J. R. Lakowicz, Eds., Kluwer, Academic/Plenum Press, 69-126 (2005) [Invited Book Chapter].

Nanoscale Probes Encapsulated By Biologically Localized Embedding (PEBBLEs) for Ion Sensing and Imaging in Live Cells, S.M. Buck, H. Xu, M. Brasuel, M.A. Philbert and R. Kopelman, Special Issue, Editors: E. Bakker and E. Pretsch, Talanta 63, 41-59, (2004).

Nano-Explorers for Brain Cancer Detection and Therapy, R. Kopelman, B.D. Ross, A. Rehemtulla, M. Philbert and Y.-E. Koo, Nature (submitted, 2004).

Non-Classical Kinetics of an Elementary A + B → C Reaction-Diffusion System Showing Effects of a Speckled Initial Reactant Distribution and Eventual Self-Segregation: Part 1 – Experiments, E. Monson and R. Kopelman, Phys. Rev. E 69,  021103-1-021103-12 (2004).

Synthesis and Characterization of Silica-embedded Iron Oxide Nanoparticles for Magnetic Resonance Imaging, F. Yan, H. Xu, J. Anker, R. Kopelman, B. Ross, A. Rehemtulla and R. Reddy, J. Nanoscience and Nanotechnology 4, 72-76 (2004).

Metal Capped Brownian Modulated Optical Nanoprobes (MOONs): From Aqueous to Biological Microenvironments, C.J. Behrend, J.N. Anker, B. H. McNaughton, M. Brasuel, M.A. Philbert, and R. Kopelman, Gerald Small Festschrift, Editors: R.M. Hochhauser, S. Mukamel and J. Norris, J. Phys. Chem 108, 10408-10414 (2004).

Brownian Modulated Optical Nanoprobes, C.J. Behrend, J.N. Anker and R. Kopelman, Appl. Phys. Lett. 84, 154-156 (2004).

Photo-Excitation Based Nano-Explorers: Chemical Analysis Inside Live Cells and Photodynamic Therapy, H. Xu, S.M. Buck, R. Kopelman, M.A. Philbert, M. Brasuel, B. Ross and A. Rehemtulla, Jortner Festschrift, Israel J. of Chem. 44, 317-337 (2004).

Photonic and Magnetic Nanoexplorers for Biomedical Use: From Subcellular Imaging to Cancer Diagnostics and Therapy, B. Ross, A. Rehemtulla, Y.-E. L. Koo, R. Reddy, G. Kim, C. Behrend, S. Buck, R.J. Schneider II, M.A. Philbert, R. Weissleder and R. Kopelman, SPIE (International Society of Photonic Engineering) 5331, 76-83 (2004).

Dimensional Crossover in the Growth of Depletion Zone in a Rectangular Capillary: Experiments and Monte Carlo Simulations, S.H. Park, H. Peng, P. Argyrakis, H. Taitelbaum and R. Kopelman, in Dynamics in Small Confining Systems VII, edited by J.T. Fourkas, P. Levitz, M. Urbakh and K.J. Wahl, Materials Research Society Symposium Proceedings 790, P7.23.1-P7.23.6 (2004). [Contributed paper]

Anomalous Kinetics of Depletion Zone Growth with One-Dimensional Geometry: Photobleaching Experimens and Simulations, H. Peng, S.H. Park, H. Taitelbaum and R. Kopelman, in Dynamics in Small Confining Systems VII, edited by J.T. Fourkas, P. Levitz, M. Urbakh and K.J. Wahl, Materials Research Society Symposium Proceedings 790, P7.15.1-P7.15-6 (2004). [Contributed paper]

Characterization and Applications of Modulated Optical Nanoprobes (MOONs), J.N.Anker, C.J. Behrend, B.H. McNaughton, T.G. Roberts, M.A. Philbert and R. Kopelman, in Dynamics in Small Confining Systems VII, edited by J.T. Fourkas, P. Levitz, M. Urbakh and K.J. Wahl, Materials Research Society Symposium Proceedings 790, P4.1.1-P4.1.12 (2004). [Invited paper]

Real-time Measurements of Dissolved Oxygen Inside Live Cells by Ormosil (Organically Modified Silicate) Fluorescent PEBBLE Nanosensors, Y.-E. Koo, Y, Cao, R. Kopelman, S.M. Koo, M. Brasuel and M.A. Philbert, Analyt. Chem. 76, 2498-2505 (2004).

Magnetic Microdrill as a Modulated Fluorescent pH Sensor, B.H. McNaughton, J.N. Anker and R. Kopelman, J. of Magnetism and Magnetic Materials 293, 696-701 (2005).

Ratiometric Fiber Optic Sensors for the Detection of Inter- and Intra-Cellular Dissolved Oxygen, E.J. Park, R.R. Reid, W. Tang, R.T. Kennedy and R. Kopelman, Journal of Materials Chemistry 15, 2913-2919 (2005).

Visualization of Vacuolar Acidification-Induced Pathogen Gene Transcription Inside Macrophages, N.M. Orozco, N. Touret, M. Zaharik, E. Park, R. Kopelman, S. Miller, B. Finlay, P. Gros and S. Grinstein, Mol. Biol. Cell (in press, 2005).

Multifunctional Nanoparticle Platforms for In Vivo MRI Enhancement and Photodynamic Therapy of a Rat Brain Cancer, R. Kopelman, M. Philbert, Y.-E.L. Koo, B.A. Moffat, G.R. Reddy, P. McConville, D.E.Hall, T.L. Chenevert, M.S. Bhojani, S.M. Buck, A. Rehemtulla and B.D. Ross, J. of Magnetism and Magnetic Materials 293, 404-410 (2005).

Photodynamic Characterization and in vitro Application of Methylene Blue Containing Nanoparticle Platforms, W. Tang, R. Kopelman, H. Xu and M. Philbert, Photochemistry and Photobiology 81, 242-249 (2005).

Ds Red as a Highly Sensitive, Selective, and Reversible Fluorescence-Based Biosensor for Both Cu⁺/Cu², J.P. Sumner, N.M. Westerberg, A.K. Stoddard, T.K. Hurst, M. Cramer, R.B. Thompson, C.A. Fierke and R. Kopelman, Biosensors and Bioelectronics (in press, 2005).

Depletion Kinetics in the Photobleaching Trapping Reaction Inside a Flat Microchannel, S.H. Park, H. Peng, R. Kopelman, P. Argyrakis and H. Taitelbaum, Phys. Rev. E 71, 031107-1- 031107-10 (2005).

Alexa Fluor 488 as an Iron Sensitive Indicator and Its Application in PEBBLE Nanosensors, J. Sumner and R. Kopelman, Analyst 130, 528-533 (2005).

Magnetically Modulated Optical Nanospheres (MagMOONS) for Detection and Quantification of Biologically Important Ions Against the Natural Background Fluorescence of Intracellular Environments, T.G. Roberts, J.N. Anker and R. Kopelman, J. of Magnetism and Magnetic Materials, J. of Magnetism and Magnetic Materials 293, 715-724 (2005).

Magnetically Modulated Optical Nanospheres (MagMOONs) and Systems, J.N. Anker, C.J. Behrend, B. McNaughton, T.G. Roberts and R. Kopelman, J. of Magnetism and Magnetic Materials 293, 655-662 (2005).

Microrheology with Modulated Optical Nanospheres (MOONs), C.J. Behrend, J.N.Anker, B.H. McNaughton and R. Kopelman, J. of Magnetism and Magnetic Materials 293, 663-670 (2005).

Cu⁺ and Cu² Sensitive PEBBLE Fluorescent Nanosensors Using Ds Red as the Reognition Element, J. P. Sumner, N. Westerberg, A.K. Stoddard, C.A. Fierke and R. Kopelman , Sensors and Actuators B (in press, 2005).

Generation and Delivery of Singlet Oxygen by Photodynamic Polyacrylamide Nanoparticles Induces Cell Death in Rat C6 Glioma Cells, R.J. Schneider, M.J. Moreno, R. Reddy, T.E. Komorowski, A. Rehemtulla, B.D. Ross, R. Kopelman and M.A. Philbert, Free Radical Biology and Medicine (submitted, 2005).

Phase-locking and Phase-slipping of Rotationally Driven Magnetic Microprobes, B.H. McNaughton, K. Kehbein, J.N. Anker and R. Kopelman, J. Phys. Chem. for Festschrift in honor of Robert Silbey (submitted, 2005).  Invited Paper

Ratiometric Singlet Oxyen Nano-optodes and Their Use for Monitoring Photodynamic Therapy Nanoplatforms, Y. Cao, Y.-E. L. Koo, S.M. Koo and R. Kopelman, Photochemistry and Photobiology (in press, 2005).

Magnetically Assisted Self-Assembly into Strawberry-like Microparticles, H. Huang, J. Anker, K. Wang and R. Kopelman, Advanced Materials (submitted, 2005).

Fabrication of Uniform Half-Shell Magnetic Nanoparticles and Microspheres with Applications as Magnetically Modulated Optical Nanoprobes, B.H. McNaughton, V. Stoica, J.N. Anker, R. Clarke and R. Kopelman, App. Phys. Letts. (submitted, 2005).

The Effect of a Slit-Shaped Trap on Deletion Kinetics Within a Microchannel, H. Peng, S.H. Park, R. Kopelman, P. Argyrakis and H. Taitelbaum, Phys. Rev. E (submitted, 2005)

Photonic Nano-Explorers as Nanosensors: Live Cell Chemical Imaging and Analysis, Y.E.L. Koo and R. Kopelman, Advanced Drug Delivery Reviews (in preparation, 2005)  Invited Review.

Fabrication of Uniform Half-Shell Magnetic Nanoparticles and Microspheres with Applications as Magnetically Modulated Optical Nanoprobes, B.H. McNaughton, V. Stoica, J.N. Anker, R. Clarke and R. Kopelman, arXiv:cond-mat/0506418 (2005).

Dye-encapsulated Nanoparticles for Two-Photon Photodynamic Therapy and Demonstration in C6-Glioma Cell Culture, D. Gao, R.R. Agayan, H. Xu, M.A. Philbert and R. Kopelman, J. Am. Chem. Soc. (submitted, 2005).

Universal, Wireless Nano-Voltmeter, K.M. Tyner, M.A. Philbert and R. Kopelman, Patent (submitted, 2005).

The Biosensors Handbook, M. Philbert and R. Kopelman, Eds., Humana Press, Inc., (in preparation, 2005).

Novel Synthetic Approaches and Photodynamic Therapy Application of Ultrafine Nano Platforms, D.Gao, H. Xu, M.A. Philbert and R. Kopelman, J. Am. Chem. Soc. Com. (submitted, 2005).

Fabrication of Uniform Magnetic Half-Shell Nanoparticles and Microspheres, B.H. McNaughton, V.A. Stoica, J.N. Anker, K. Tyner, R. Clarke and R. Kopelman, Proc. Mat. Res. Society (submitted, 2005).

Ultrafine Nanogel Particles: Synthetic Approach and Photodynamic Therapy, D. Gao, H. Xu, M.A. Philbert and R. Kopelman, J. Am. Chem. Soc. Com (submitted, 2005)