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CT-Based Local Distribution Metric Improves Characterization of COPD
A bifunctional MAPK/PI3K antagonist for inhibition of tumor growth and metastasis
Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168)
Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K)
Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model
Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer
Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor
Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer
Imaging Proteolytic Activity in Live Cells and Animal Models
Impact of perfusion map analysis on early survival prediction accuracy in glioma patients
Diffusion-weighted MRI as a biomarker of tumor radiation treatment response heterogeneity: A comparative study of whole-volume histogram analysis versus voxel-based functional diffusion map analysis
Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma
DW-MRI as a predictive biomarker of radiosensitization of GBM through targeted inhibition of checkpoint kinases
Noninvasive monitoring of pharmacodynamics and kinetics of a death receptor 5 antibody and its enhanced apoptosis induction in sequential application with doxorubicin
Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice
Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression
DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma model
Parametric response mapping of CT images provides early detection of local bone loss in a rat model of osteoporosis
Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer
DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Multimodality imaging of tumor and bone response in a mouse model of bony metastasis
Prospective analysis of parametric response map-derived MRI biomarkers: Identification of early and distinct glioma response patterns not predicted by standard radiographic assessment
Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-Deficient PDGF-driven murine glioblastoma
Diffusion-weighted MRI for assessment of early cancer treatment response
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination
Role of HuR and p38 MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT
Applications of molecular imaging
XIAP as a ubiquitin ligase in cellular signaling
HuR regulates gap junctional intercellular communication by controlling β-catenin levels and adherens junction integrity
Factors interacting with HIF-1α mRNA: Novel therapeutic targets
Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation
Ubiquitin-mediated proteolysis of HuR by heat shock
Cytoprotective effects of IAPs revealed by a small molecule antagonist
Caspases and IAPs: A Dance of Death Ensures Cell Survival
Nuclear HuR accumulation through phosphorylation by Cdk1
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1α
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP
Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells
Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
Posttranscriptional Derepression of GADD45α by Genotoxic Stress
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
Von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays
Negative feedback regulation of MKK6 mRNA stability by p38α mitogen-activated protein kinase