Caution:
The reaction you are about to see was designed by trained chemists. It is extremely tedious and should not be attempted by anyone, anywhere, anytime...outside the lab!
Total Synthesis of (-)-Morphine
Koizumi, H.; Yokoshima, S.; Fukuyama, T. Chem. Asian J. 2010, 5, (2192 – 2198)
This article explores how to effectively synthesize (-)-morphine, a very important analgesic, in order to create a non-addictive derivative. The transformation seen above is just one step of many to complete the synthesis.
Transformation of 21 to 22:
