2014 WINTER Term Chalk Talk Schedule

January 22
February 19
March 19
April 23
May 21

All Chalk Talks are held in 1201 CHEM, 12:00pm-1:30pm


Please let Conor Doss know if you would like to volunteer for future Chalk Talks for the 2013-2014 Academic Year.


Sept 19, 2012   Using Irreversible Kinase Inhibitors to Study Protein Dynamics- by Frank Kwarcinski, Medicinal Chemistry, Soellner Lab

The p300 CH1 and HAT domains regulate NANOG expression in cancer cells - by Conor Doss, Chemical Biology, Mapp Lab

April 18, 2012 Carol Ann Pitcairn 12:00pm-1:00pm-1201 CHEMISTRY BLDG
March 21, 2012 Alison Tebo & Steffen Bernard 12:00pm-1:00pm-1201 CHEMISTRY BLDG
February 22, 2012 Derek Lyons & Ronald Jenkins

Mapping Mutations, Eliminating Errors, Finding Frameshifts -Derek Lyons

High-throughput Screening to Identify Molecular Probes of Early Acyltransferases of Lipid A Biosynthesis- Ronald Jenkins

Jan 18, 2012 Solymar Negrettii & Conor Doss

Exploring Macrolide P450 enzymes as bio-catalysts for C-H activation-Solymar Negretti

Investigating the biological effects of CBP KIX domain inhibition by depside natural products- Conor Doss

Dec 14, 2011 Carol Ann Pitcairn & Melissa Zastrow

Determining the metal selectivity of histone deacetylase 8 -Carol Ann Pitcairn

Kinetic studies of de novo designed zinc peptides: incorporating second-sphere interactions- Melissa Zastrow

Nov 16, 2011 Frank Kwarcinski & Conor Doss

Selective Protein Tyrosine Kinase Inhibition Through Non-Conserved Binding Modes -Frank Kwarcinski

Small molecule inhibition of NANOG in cancer-initiating cells- Conor Doss

Oct 19, 2011 Jon Whicher & Erin Miller

Characterization of Curacin Docking Domains "-Jon Whicher

The interaction of AlkA and Lesion Containing DNA"- Erin Miller

Sept. 21, 2011

Solymar Negretti & Steffen Bernard



Synthesis and evaluation of unnatural substrates for C-H activation studies employing macrolide biosynthethic P450s as catalysts -Solymar Negretti

Using a peptide mimic of an acyl carrier protein domain in structural studies of polyketide synthase ketoreductase domains- Steffen Bernard

April 27,2011

Jon Whicher & Derek Lyons



Characterization of the Docking Domains from the Curacin A biosynthetic Pathway  - Jon Whicher

Glycosylase Recognition of Damaged DNA: Balancing Mutagenesis and Repair - Derek Lyons

March 30,2011

Steffen Bernard & Chris Rath



The Structural Basis of Stereochemistry in Polyketide Natural Products  - Steffen Bernard

Alternative methodologies for exploring the predicted biochemistry of the ET-743 biosynthetic - Chris Rath

Feb. 23,2011

Solymar Negretti & Melissa Zastrow



Evaluating PikC as a catalyst for C-H activation through substrate engineering - Solymar Negretti

De novo designed metallopeptides to mimic metal sites in nature - Melissa Zastrow

Jan. 26, 2011 Chris Taylor & Jeff Hill

Small molecule modulation of erbB2 overexpression -Chris Taylor

Corronoid Iron Sulfur Protein: Key Component of the Wood-Ljungdahl Pathway - Jeff Hill

Jan. 19, 2011

Donald Raymond & Ronald Jenkins


Meeting held with CBI-IDP students

"Structural biology of Rift Valley fever virus nucleocapsid protein" - Donald Raymond

"Probing Early Acyltransferases of Lipid A Biosynthesis"- Ronald Jenkins

Nov. 24, 2010 Melissa Zastrow & Chris Rath

Hydrolytic catalysis and structural stabilization in a de novo-designed metalloprotein" - Melissa Zastrow

Culture-independent characterization of a key gene cluster in a marine tunicate bacterial symbiont system: multi-omic investigations into ET-743 biosynthesis- Chris Rath

Oct. 27, 2010 Derek Lyons & Jonathon Whicher

Rebelious Repair: Mutations Caused by DNA Repair - Derek Lyons

Investigating the stereochemical control of polyketide synthase ketoreductases - Jonathon Whicher

Sept. 29, 2010

Solymar Negretti

& Ronald Jenkins

Synthesis of Unnatural Substrates for PikC Oxidation Studies - Soylmar Negretti

Phage Display for Discovery of Peptides Probing Early Acyltransferases of Lipid A Biosynthesi" - Ron Jenkins


April 14, 2010

Matt Leathen

The facile preparation of protected benzylic and heteroarylmethyl amines via room temperature Curtius rearrangements

  Christopher Taylor Curbing overexpression of erbB2 by mimicking a transcriptional activation domain
Mar 24, 2010 Donald Raymond

Structural Biology of RNA Viral Protein

  Dustin Patterson Symmetry Assembled Protein Cages
Feb. 17, 2010 Jonathon Whicher 2.17Å structure of a thioesterase from the prodiginine biosythetic pathway with a novel role in intermediate transfer
April 29, 2008 Matt Leathen
Curtis Schneider
    Meeting held with CBI-IDP students this month
Mar 25, 2008   Discussion on choosing a post-doc and career development led by Professor Pecoraro
Feb 26, 2008

Levi Blazer
Edgar Lee

Jan 29, 2008 Sara Buhrlage “Regulation of Transcription with Small Molecules”
  Susan Wiedner “Synthetic Studies Toward Aziridinomitosenes”
    Meeting held with CBI-IDP students this month
Nov 27, 2007 Chris Rath “Utilizing mass spectrometry to investigate polyketide biosynthesis”
  Bob Rarig “Hydroboration of homoallylic alcohols”
Oct 30, 2007 Becky Roof "Peptide Ligands of Regulators of G-Protein Signaling 4 (RGS4) from a One-Bead, One-Compound Library Screen".
  Dustin Patterson "Investigations in Coiled-coil Assembly of Protein Superstructures"
Sep 25, 2007 Prof. Pecoraro Introduction

For more information about the CBI Training Grant, email: CBI.Gen.Info@umich.edu